Abstract #1941
Phospholipid and high-energy phosphate levels in multiple brain regions in Alzheimers disease: a 3D 31 P-MRSI study
Anne Rijpma 1,2 , Marinette van der Graaf 3,4 , Olga Meulenbroek 1,2 , Rianne de Heus 1 , Marcel G.M. Olde Rikkert 1,2 , and Arend Heerschap 3
1
Geriatric Medicine, Radboud university
medical center, Nijmegen, Gelderland, Netherlands,
2
Radboud
Alzheimer Centre, Radboud university medical center,
Nijmegen, Gelderland, Netherlands,
3
Radiology,
Radboud university medical center, Nijmegen, Gelderland,
Netherlands,
4
Paediatrics,
Radboud university medical center, Nijmegen, Gelderland,
Netherlands
3D
31
P-MRSI
was performed to assess whether regional variation could
be observed in phospholipid and energy metabolism in 17
patients with mild Alzheimer Disease (AD). The results
showed significantly (P<.01) higher PE and PC content
for anterior cingulate cortex (ACC) than for retrospinal
cortex (RSC). In addition, differences in high energy
phosphates were found, with high Pi and NAD, low PCr and
ATP for the ACC, and high PCr, low ATP, Pi and NAD for
the RSC, both compared with contents obtained in the
hippocampi. These variations indicate regional
differences in phosphorus metabolism in the mild AD
brain.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
