Abstract #1942
Neurite orientation dispersion and density imaging (NODDI) to investigate tau pathology in a TG4510 mouse model of Alzheimers
Niall Colgan* 1 , Bernard Siow* 1,2 , James M O'Callaghan 1 , Jack A Wells 1 , Holly E Holmes 1 , Nick M Powell 1,2 , Ozama Ismail 1 , Simon Richardson 1,2 , Daniel C Alexander 2 , Emily C Collins 3 , Michael O'Neill 4 , Hui Zhang* 2 , and Mark F Lythgoe* 1
1
Centre for Advanced Biomedical Imaging,
University College London, London, United Kingdom,
2
Centre
for Medical Image Computing, University College London,
London, United Kingdom,
3
Eli
Lilly and Company, Indianapolis, United States,
4
Eli
Lilly & Co. Ltd, Surrey, United Kingdom
We applied neurite orientation dispersion and density
imaging (NODDI) to estimate the microstructural changes
due to tau pathology in the TG4510 (TG) animal model of
Alzheimers disease (AD). The mouse model overexpresses
a mutant human tau (P301L) resulting in intercellular
tauopathies largely restricted to the hippocampus,
cortex, olfactory bulb, and striatum. NODDI metrics
discriminated between the wild type (WT) and TG is
distinct regions of the brain associated with pathology.
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