Abstract #1943
4D Flow MRI for intracranial hemodynamic assessment in Alzheimers Disease
Leonardo A. Rivera-Rivera 1 , Eric M. Schrauben 1 , Sterling C. Johnson 2 , Kevin M. Johnson 1 , Michael Loecher 1 , Patrick Turski 2 , Chuck Illingworth 2 , and Oliver Wieben 1,3
1
Medical Physics, University of Wisconsin,
Madison, Wisconsin, United States,
2
Medicine,
University of Wisconsin, Madison, Wisconsin, United
States,
3
Radiology,
University of Wisconsin, Madison, Wisconsin, United
States
Cerebral arteries are often morphologically altered and
dysfunctional in Alzheimers disease. In this pilot
study, 4D flow MRI was used to measure intra-cranial
flow features, particularly mean flow and pulsatility
index, in patients with AD and in healthy controls. We
found a statistically significant decrease in mean flow
and increase in pulsatility index for the AD patients.
With the large volume coverage and high temporal and
spatial resolution demonstrated here, 4D flow MRI can
provide additional biomarkers of vascular health that
can contribute to the identifying patients who could
benefit from interventions to improve circulatory system
functions.
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