Abstract #1945
White Matter Hyperintensities and Physical Activity in People at Risk of Alzheimer's Disease
Bernd Merkel 1,2 , Nicola T. Lautenschlager 3 , Kay Cox 4 , David Ames 2,5 , Kathryn A. Ellis 3 , Elizabeth Cyarto 5 , Pramit Phal 1 , Bob Tran 2 , Christopher Steward 1,2 , and Patricia M. Desmond 1,2
1
Radiology, Royal Melbourne Hospital,
Parkville, VIC, Australia,
2
The
University of Melbourne, VIC, Australia,
3
Psychiatry,
The University of Melbourne, VIC, Australia,
4
University
of Western Australia, Perth, Western Australia,
Australia,
5
National
Ageing Research Institute, Parkville, VIC, Australia
White matter hyperintensities (WMH), which appear bright
on T2-FLAIR images, are considered to reflect pathology
of brain vessels and have been linked to age-related
cognitive changes as well as cognitive impairments and
complaints. Physical activity (PA) may be a modifiable
and potentially protective factor for Alzheimers
Disease (AD). However, its effect on cerebrovascular
disease and AD is still not clear. We segmented and
quantified WMH and hippocampal volumes of patients with
subjective memory complaints (SMC) and mild cognitive
impairments (MCI), who are at increased risk of
developing AD. The volumes were associated with
different exercise-related assessments of PA.
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