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Abstract #1946

Magnetic susceptibility in subcortical gray matter is associated with Alzheimer's pathology: An ex-vivo QSM-pathology investigation in a community cohort

Arnold Moya Evia Jr 1 , David A Bennett 2,3 , Julie A Schneider 2,3 , Aikaterini Kotrotsou 1 , Robert J Dawe 2 , and Konstantinos Arfanakis 1,2

1 Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2 Rush Alzheimer's Disease Center, Chicago, Illinois, United States, 3 Rush University Medical Center, Chicago, Illinois, United States

Iron accumulation in the brain has been associated with aging, and Alzheimers disease (AD). MRI techniques that allow detection of iron accumulation may lead to development of biomarkers of AD pathology. Quantitative susceptibility mapping (QSM) was introduced recently, and is shown to be sensitive to changes in iron levels. Therefore, the purpose of this study was to investigate the neuropathologic correlates of magnetic susceptibility in subcortical gray matter, by conducting the first ex-vivo QSM-pathology investigation in a community cohort.

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