Abstract #1946
Magnetic susceptibility in subcortical gray matter is associated with Alzheimer's pathology: An ex-vivo QSM-pathology investigation in a community cohort
Arnold Moya Evia Jr 1 , David A Bennett 2,3 , Julie A Schneider 2,3 , Aikaterini Kotrotsou 1 , Robert J Dawe 2 , and Konstantinos Arfanakis 1,2
1
Biomedical Engineering, Illinois Institute
of Technology, Chicago, IL, United States,
2
Rush
Alzheimer's Disease Center, Chicago, Illinois, United
States,
3
Rush
University Medical Center, Chicago, Illinois, United
States
Iron accumulation in the brain has been associated with
aging, and Alzheimers disease (AD). MRI techniques that
allow detection of iron accumulation may lead to
development of biomarkers of AD pathology. Quantitative
susceptibility mapping (QSM) was introduced recently,
and is shown to be sensitive to changes in iron levels.
Therefore, the purpose of this study was to investigate
the neuropathologic correlates of magnetic
susceptibility in subcortical gray matter, by conducting
the first ex-vivo QSM-pathology investigation in a
community cohort.
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