Meeting Banner
Abstract #1947

Possible Compensatory Plasticity of Anterior Thalamic Nucleus to Memory Impairment In Normal Pressure Hydrocephalus Patients Manifested As Increased Anisotropy and Fiber Density

Yung-Chieh Chen 1 , Cheng-Yu Chen 2,3 , Shih-Wei Chiang 4,5 , Hsiao-Wen Chung 5 , Yu-Te Wu 1 , Ping-Huei Tsai 2 , Yi-Hsiu Hsiao 2 , Ming-Chung Chou 6 , Hung-Wen Kao 4 , and Chao-Ying Wang 4

1 Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 2 Department of Medical Imaging and Imaging Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, 3 Graduate Institue of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, 4 Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan, 5 Graduate Institute of Biomedical Electrics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 6 Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

Idiopathic normal pressure hydrocephalus (NPH) is manifested clinically with classic triad of gait disturbance, incontinence and dementia. Quantification of anisotropy in terms of metrics such as the fractional anisotropy (FA) offers insight into microstructure alternations. The purpose of this study is to examine the diffusion tensor parametric behavior of anterior thalamic nucleus in response to memory changes in normal pressure hydrocephalus. Our study indicated that alternations of diffusion tensor metrics can be measured in thalamic nucleus responsible for memory in NPH patient, which may have potential clinical implications for responses monitoring at microstructure level in NPH patients under treatment.

This abstract and the presentation materials are available to members only; a login is required.

Join Here