Abstract #1948
WHITE MATTER LESIONS ACCOUNT FOR APATHY SYMPTOMS IN AMNESTIC MILD COGNITIVE IMPAIRMENT: A VOXEL BASED LESION SYMPTOM MAPPING STUDY
Mario Torso 1 , Laura Serra 1 , Giovanni Giulietti 1 , Roberta Perri 2 , Lucia Fadda 2,3 , Barbara Span 1 , Camillo Marra 4 , Mara Cercignani 1,5 , Carlo Caltagirone 2,3 , and Marco Bozzali 1
1
Neuroimaging Laboratory, Santa Lucia
Foundation, IRCCS, Rome, Italy,
2
Department
of Clinical and Behavioural Neurology, Santa Lucia
Foundation, IRCCS, Rome, Italy,
3
Department of
Neuroscience, University of Rome "Tor Vergata", Rome,
Italy,
4
Institute
of Neurology, Universit Cattolica, Rome, Italy,
5
Clinical
Imaging Sciences Centre, Brighton & Sussex Medical
School, Brighton, United Kingdom
This study, using Voxel-based lesionsymptom mapping
(VSLM) and Voxel Based Morphometry analysis (VBM),
investigated the contribution of White Matter lesions
and regional grey matter atrophy in determining
behavioural symptoms in patients with amnestic mild
cognitive impairment (a-MCI), which is widely regarded
as a prodromal stage of Alzheimer disease. Behavioural
symptoms were quantified by Neuropsychiatric
Inventory-12 (NPI-12). The main finding of the study was
that a selective and bilateral lesion damage to the
anterior thalamic radiation (ATR) was strictly
associated to the presence and severity of patients
apathy, in the absence of any contribution from regional
grey matter loss.
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