Abstract #1949
Correlation of magnetization transfer (MT) and diffusion MRI in sporadic Creutzfeldt-Jacob disease
Gunther Helms 1 , Markus Matros 2 , Kai Kallenberg 3 , Niels K Focke 4 , Inga Zerr 5 , Walter J Schulz-Schaeffer 6 , and Peter Dechent 1
1
Cognitive Neurology, Gttingen University
Medical Center, Gttingen, Germany,
2
Imaging
Diagnostics and Interventional Radiology, Klinikum
Wolfsburg, Wolfsburg, Germany,
3
Neuroradiology,
Gttingen University Medical Center, Gttingen, Germany,
4
Neurology,
Tbingen University Hospital, Tbingen, Germany,
5
Neurology,
Gttingen University Medical Center, Gttingen, Germany,
6
Neuropathology,
Gttingen University Medical Center, Gttingen, Germany
Reduced diffusivity is the radiological hallmark of
spongiform degeneration of the basal ganglia in sporadic
Creutzfeldt-Jacob disease (sCJD) which is difficult to
detect by structural T1-weighted MRI. Using a novel
semi-quantitative parameter for magnetization transfer
(MT) with a high intrinsic contrast within GM, the
MT-saturation, a significant reduction of MT was found
in 5 sCJD patients compared to controls in caudate and
putamen. This was correlated to the reduction in mean
diffusivity thus associating hindered diffusion to
increased water content. This can be explained by the
influence of microcysts on diffusion and MT.
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