A longitudinal study of the corpus callosum size and shape in early Alzheimers disease

We studied the rate of change of the area and circularity (CIR) of the corpus callosum in normal aging and early AD using 75 normal controls (NC), 51 mild cognitively impaired (MCI), and 21 mild AD (AD) subjects, scanned about two years apart. Programs automatically segmented and measured the CC. The CIR declined significantly with time in all three groups. Furthermore, the rates of decline were significantly different between groups. Change in the circularity of the corpus callosum may be a useful imaging biomarker of AD progression.

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