A whole brain approach of multimodal neuroimaging techniques for in vivo investigation of brain tissue changes in Alzheimer's Disease
Maria Marcella Lagan 1 , Niels Bergsland 1,2 , Mario Clerici 1,3 , Pietro Cecconi 1 , Giuseppe Baselli 2 , Raffaello Nemni 1,3 , and Francesca Baglio 1
Fondazione Don Carlo Gnocchi ONLUS, Milan,
of Electronics, Information and Bioengineering,
Politecnico di Milano, Milan, Milan, Italy,
Department, Universit degli Studi di Milano, Milan,
Recent MRI studies investigated the relationship between
gray (GM) and white matter (WM) alterations in
Alzheimers Disease, selecting areas known to be altered
in AD and correlating their volumetric and DTI indices.
We performed TBSS of 22 AD patients vs 23 healthy
controls, mapped the results to the JHU-WM atlas,
computed mean FA values of significant voxel
corresponding to each atlas region and correlated them
to GM volume, using VBM of the whole brain. A
significant correlation between WM integrity and volume
of near GM regions were obtained. The cause/effect
interpretation of these results requires longitudinal
multimodal MRI studies.
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