Functional and Structural Alterations Induced by Cognitive Behavioral Therapy in Social Anxiety Disorder
Yoshiyuki Hirano 1,2 , Takayuki Obata 1,2 , Chihiro Sutoh 1,2 , Daisuke Matsuzawa 1,2 , Naoki Yoshinaga 1,2 , Zhongming Liu 3 , Hiroshi Ito 2 , Hiroshi Tsuji 2 , and Eiji Shimizu 1
Research Center for Child Mental
Development, Chiba University, Chiba, Chiba, Japan,
Institute of Radiological Sciences, Chiba, Chiba, Japan,
of Electrical and Computer Engineering, Purdue
University, West Lafayette, IN, United States
We set out to investigate rsfMRI and DTI to assess the
effect of cognitive behavioral therapy (CBT) on neural
networks in patients with selective serotonin reuptake
inhibitor (SSRI)-resistant social anxiety disorders
(SAD). Increased neuronal connectivity at rest was found
between the dorsal anterior cingulate cortex and
striatum after 16-week CBT compared with healthy
subjects. Also, decreased FA value was observed in the
right anterior limb of the internal capsule after CBT.
These results suggested that changes in
emotional-related neural circuit by CBT exposed
alterations in functional and structural MRI.
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