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Abstract #1961

Regional EEG Theta Increase enhances fMRI activity findings in a simultaneous EEG/fMRI study during Auditory Hallucinations in Chronic Schizophrenic Patients

Beatriz Dionisio 1,2 , Gracin Garca Mart 1,3 , Conrado J Calvo 4 , Nicols Pearanda 2 , Ana Beatriz Solana 5 , J. A. Hernndez-Tamams 5 , Luis Mart-Bonmat 3 , and Julio Sanjun 1,2

1 University of Valencia, CIBERSAM, Valencia, Valencia, Spain, 2 Instituto de Investigacin Sanitaria, INCLIVA, Valencia, Valencia, Spain, 3 Servicio de Radiologa, Hospital Quirn de Valencia, Valencia, Spain, 4 Instituto ITACA-Bio. Universitat Politcnica de Valncia, Grupo Electrofiosiologa y Bioingenera (GEB), Valencia, Spain, 5 Fundacin CIEN, Fundacin Reina Sofa, Madrid, Spain

The pathophysiology of Auditory Hallucinations in Schizophrenia remains poorly understood due to the complexity to capture the spontaneous episodes and lack of knowledge about its neuronal dynamics. By using simultaneous EEG/fMRI techniques, we aimed to identify power spectral differences of brain waves, linking regional findings to intrinsic hemodynamic activations leading to AHs in chronic patients. Our results suggest that simultaneous EEG/fMRI seems to be a promising technique for thorough investigation on AHs neural spatiotemporal mechanisms alleviating technical limitations. Both modalities were correlated during the spontaneous AHs, with specific regional increase in theta EEG activity and hemodynamic activations in auditory and language cortical areas.

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