Abstract #1963
Disrupted modular organization and abnormal topological properties of the ACC in abstinent alcohol dependent patients to alcohol-cue reactivity
Guoying Wang 1 , Traute Demirakca 1 , Markus Sack 1 , Sabine Vollstaedt-Klein 2 , Derik Hermann 2 , Matthias Ruf 1 , Karl Mann 2 , and Gabriele Ende 1
1
Department of NeuroImaging, Central
Institute of Mental Health, Medical Faculty Mannheim,
University of Heidelberg, Mannheim, Germany,
2
Department
of Addiction Medicine, Central Institute of Mental
Health, Medical Faculty Mannheim, University of
Heidelberg, Mannheim, Germany
Brain activation in ACC to alcohol-related cues is able
to elicit craving and relapse. In this ongoing study we
used graph theory to test modular organization and
topological properties of the ACC in abstinent alcohol
dependent patients response to alcohol-associated cues.
Repeated ANOVA analysis shows a trend towards decreased
modularity in patients over early abstinence in which
modular size as well as modular composition changed.
This trend for less modularity implies an increasingly
disrupted modular organization over early abstinence.
Moreover, the ACC seems to be a hub in whole brain
network with abnormal activity/importance in patients.
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