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Abstract #1964

Altered anterior cingulate chemistry, blood flow, and functional connectivity in schizophrenia

Benjamin W Krause 1 , S Andrea Wijtenburg 1 , Frank Gaston 1 , Sarah Nisonger 1 , Stephanie Korenic 1 , and Laura Rowland 1,2

1 MPRC, University of Maryland School of Medicine, Baltimore, MD, United States, 2 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

This study combined proton magnetic resonance spectroscopy, arterial spin labeling, and resting state fMRI to investigate anterior cingulate neurochemistry, regional cerebral blood flow, and functional connectivity in participants with schizophrenia and healthy controls. Patients had significantly lower tNAA levels than controls. Additionally, tNAA was positively correlated with cerebral blood flow, and this relationship was found to be weaker in patients than controls. We also found altered anterior cingulate functional connectivity in patients, however, tNAA was not significantly correlated with AC functional connectivity in patients or controls.

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