Abstract #1966
White matter abnormalities in schizophrenia: A diffusion spectrum imaging study using whole brain tract-specific analysis
Yu-Jen Chen 1 , Chun-Chieh Fan 2 , Yung-Chin Hsu 1 , Yu-Chun Lo 1 , Chih-Ming Liu 3 , and Wen-Yih Isaac Tseng 1
1
Center for Optoelectronic Medicine, National
Taiwan University College of Medicine, Taipei, Taipei,
Taiwan,
2
Department
of Cognitive Science, UC San Diego, CA, United States,
3
Department
of Psychiatry, National Taiwan University Hospital,
Taipei, Taipei, Taiwan
In this study, we employed a high throughput
tract-specific analysis, called tract-based automatic
analysis, and a feasible statistical testing by
performing threshold-free cluster enhancement (TFCE) and
controlling family-wise error rate (FWER) to investigate
the abnormalities of white matter tracts in
schizophrenia using diffusion spectrum imaging. Our
results showed consistent findings in association fibers
and callosal fibers with previous studies. Furthermore,
we also found many significant differences in projection
fibers, such as frontal-striatal tracts and
thalamo-cortical tracts. Moreover, clusters with
significant difference could be discovered after
applying TFCE and controlling FWER.
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