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Abstract #1967

Chronic repetitive transcranial magnetic stimulation-induced increases in GABAergic neurotransmission in chronic unpredictable mild stress rat model: 1H-NMR spectroscopy study at 11.7 T

Sang-Young Kim 1 , Do-Wan Lee 1 , Hyunju Kim 2 , Eunjung Bang 2 , and Bo-Young Choe 1

1 Department of Biomedical Engineering, The Catholic University of Korea, Seoul, Seoul, Korea, 2 Korea Basic Science Institute, Seoul, Korea

In this study, we investigated the effects of chronic repetitive transcranial magnetic stimulation on GABA level in chronic unpredictable mild stress model using 1H-NMR spectroscopy. The prefrontal cortex and hippocampus tissues were harvested from rats brain and the spectra obtained from CPMG sequence were analyzed by LCModel. There were significant differences in GABA concentrations in chronic rTMS-treated rats compared to controls. Our finding indicates that chronic rTMS has a modulatory effect on GABAergic systems, suggesting its beneficial effects.

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