Abstract #1967
Chronic repetitive transcranial magnetic stimulation-induced increases in GABAergic neurotransmission in chronic unpredictable mild stress rat model: 1H-NMR spectroscopy study at 11.7 T
Sang-Young Kim 1 , Do-Wan Lee 1 , Hyunju Kim 2 , Eunjung Bang 2 , and Bo-Young Choe 1
1
Department of Biomedical Engineering, The
Catholic University of Korea, Seoul, Seoul, Korea,
2
Korea
Basic Science Institute, Seoul, Korea
In this study, we investigated the effects of chronic
repetitive transcranial magnetic stimulation on GABA
level in chronic unpredictable mild stress model using
1H-NMR spectroscopy. The prefrontal cortex and
hippocampus tissues were harvested from rats brain and
the spectra obtained from CPMG sequence were analyzed by
LCModel. There were significant differences in GABA
concentrations in chronic rTMS-treated rats compared to
controls. Our finding indicates that chronic rTMS has a
modulatory effect on GABAergic systems, suggesting its
beneficial effects.
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