Abstract #1969
Regional increases of cortical thickness in untreated, first-episode major depressive disorder
Su Lu 1 , Lihua Qiu 2 , John A. Sweeney 3 , and Qiyong Gong 2
1
West China Hospital, Chengdu, Sichuan,
China,
2
West
China Hospital, Sichuan, China,
3
University
of Texas Southwestern, TX, United States
Most previous structural studies of major depressive
disorder (MDD) investigated volumetric changes in
chronic medicated patients. In the present study, we
investigate both the cortical thickness and surface area
changes in first-episode, treatment-nave, mid-life MDD.
By studying 46 first-episode, treatment-nave, mid-life
adult MDD patients and 46 matched controls, we firstly
observed greater rather than reduced cortical thickness
at early stage of MDD. These changes in first-episode,
treatment-nave, mid-life MDD patients may reflect an
active illness-related cortical change close to illness
onset, and thus may provide important new insight into
the early neurobiological manifestations of the
disorder.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
