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Abstract #1972

Decreased Resting-state Functional Connectivity in Dorsolateral Prefrontal Cortical Networks Correlates with Deficient Visual Working Memory Performance in Adult Macaques with Neonatal Hippocampal Lesion

Yuguang Meng 1 , Xiaoping Hu 2 , Jocelyne Bachevalier 3 , and Xiaodong Zhang 1

1 Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2 Biomedical Engineering, Emory University, Atlanta, GA, United States, 3 Yerkes National Primate Research Center and Department of Psychology, Emory University, Atlanta, GA, United States

Previous studies showed that visual working memory dependent on dorsolateral prefrontal cortex (dlPFC) was impaired in adult rhesus macaques after neonatal hippocampal lesions. To further explore the neuronal substrates for the deficient working memory performances, the integrity of the whole functional network of dlPFC was examined by resting-state fMRI and correlations were found between the functional connectivity in the dlPFC network and the working memory performances.

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