Abstract #1972
Decreased Resting-state Functional Connectivity in Dorsolateral Prefrontal Cortical Networks Correlates with Deficient Visual Working Memory Performance in Adult Macaques with Neonatal Hippocampal Lesion
Yuguang Meng 1 , Xiaoping Hu 2 , Jocelyne Bachevalier 3 , and Xiaodong Zhang 1
1
Yerkes National Primate Research Center,
Emory University, Atlanta, GA, United States,
2
Biomedical
Engineering, Emory University, Atlanta, GA, United
States,
3
Yerkes
National Primate Research Center and Department of
Psychology, Emory University, Atlanta, GA, United States
Previous studies showed that visual working memory
dependent on dorsolateral prefrontal cortex (dlPFC) was
impaired in adult rhesus macaques after neonatal
hippocampal lesions. To further explore the neuronal
substrates for the deficient working memory
performances, the integrity of the whole functional
network of dlPFC was examined by resting-state fMRI and
correlations were found between the functional
connectivity in the dlPFC network and the working memory
performances.
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