Meeting Banner
Abstract #1973

Effects of Lisdexamfetamine on prefrontal brain activation, glutamate concentration and executive function in menopausal women with memory complaints: A double-blind placebo controlled crossover study at 7T

Ravi Prakash Reddy Nanga 1 , Simon Vandekar 2 , Sheila Shanmugan 2,3 , Sarah Conlin 2,3 , Kejia Cai 1 , Mark A Elliott 1 , Hari Hariharan 1 , Jeanette Bradley 2,3 , Ravinder Reddy 1 , and Neill C Epperson 2,3

1 Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2 Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 3 Penn Center for Womens Behavioral Wellness, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Menopausal women frequently report new onset decline in memory, focus, and organization- domains of cognition referred to as executive functions (EFs). Loss of estradiol effects on dopaminergic systems in the prefrontal cortex is thought to contribute to this phenomenon. We sought to test whether the psychostimulant lisdexamphetamine (LDX) improves EF in menopausal women and whether drug-induced changes in prefrontal glutamate and neural activation (measured at 7T) are responsible for improved working memory. This is the first study of its kind and may provide evidence to support LDX treatment in women with EF complaints related to natural or surgical/chemotherapy-induced menopause.

This abstract and the presentation materials are available to members only; a login is required.

Join Here