Meeting Banner
Abstract #1976

A diffusion tensor imaging study of white matter microstructure concerning suicidality in major depressive disorder

Huawei Zhang 1 , Zhiyun Jia 1 , Sugai Liang 2 , Li Yin 2 , Yi Huang 2 , Qiyong Gong 1 , and Xiaoqi Huang 1

1 Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, Sichuan, China, 2 Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, Sichuan, China

Previous researches of suicide in depression always focused on either suicidal behavior or ideation. Present study aimed to give a more complete profile for the white matter microstructural abnormalities in depressive patients concerning suicide behavior. We found significant decrease in FA in the splenium corpus callosum in depressive patients comparing with healthy controls via MRI scans for diffusion tensor imaging and suicide attempters showed more significant decrease than patients without suicide attempt. Our results suggest that depression and suicide are associated with microstructure abnormalities of the white matter and people with suicide history have more severe cerebral alteration.

This abstract and the presentation materials are available to members only; a login is required.

Join Here