Abstract #1976
A diffusion tensor imaging study of white matter microstructure concerning suicidality in major depressive disorder
Huawei Zhang 1 , Zhiyun Jia 1 , Sugai Liang 2 , Li Yin 2 , Yi Huang 2 , Qiyong Gong 1 , and Xiaoqi Huang 1
1
Huaxi MR Research Center (HMRRC), West China
Hospital, Sichuan University, Chengdu, Sichuan, China,
2
Department
of Psychiatry, West China Hospital, Sichuan University,
Chengdu, Sichuan, China
Previous researches of suicide in depression always
focused on either suicidal behavior or ideation. Present
study aimed to give a more complete profile for the
white matter microstructural abnormalities in depressive
patients concerning suicide behavior. We found
significant decrease in FA in the splenium corpus
callosum in depressive patients comparing with healthy
controls via MRI scans for diffusion tensor imaging and
suicide attempters showed more significant decrease than
patients without suicide attempt. Our results suggest
that depression and suicide are associated with
microstructure abnormalities of the white matter and
people with suicide history have more severe cerebral
alteration.
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