Abstract #1983
MRS in early stage psychosis: Dependence on tissue fraction correction
Sin E. Robson 1 , Emma L. Hall 1 , Matthew J. Brookes 1 , Lena Palaniyappan 2 , Peter F. Liddle 2 , Mary C. Stephenson 1 , Molly Simmonite 2 , Elizabeth B. Liddle 2 , Michael Skelton 2 , Nikolaos G. Christodoulou 2 , Ayaz Qureshi 3 , and Peter G. Morris 1
1
School of Physics and Astronomy, University
of Nottingham, Nottingham, Notts, United Kingdom,
2
Faculty
of Medicine and Health Sciences, University of
Nottingham, Nottingham, Notts, United Kingdom,
3
Nottinghamshire
Healthcare NHS Trust, NHS, Nottingham, Notts, United
Kingdom
Abnormalities in structure, function and
neurotransmission are seen in patients with psychosis,
particularly in nodes of the salience network: the
anterior cingulate cortex (ACC) and insula. This study
used 7T MRI and MRS to investigate tissue composition
and metabolite concentrations in these regions and an
occipital control region. Reductions in white matter
were found in patients insula, along with decreases in
glutamate concentration. Correction for tissue fraction
removed the difference in glutamate, perhaps
erroneously, since glutamate is mostly present in grey
matter but differences in tissue fraction between
patients and controls were seen in white matter only.
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