Abstract #1990
Changes in Gray Matter Volumes Induced by Repetitive Transcranial Magnetic Stimulation in Drug-resistant Major Depression
Tai-Ying Liu 1,2 , Guan-Hua Huang 1 , Cheng-Ta Li 3,4 , Yong-Sheng Chen 5 , Tung-Ping Su 3,4 , Jen-Chuen Hsieh 1,2 , and Li-Fen Chen 1,2
1
Institute of Brain Science, National
Yang-Ming University, Taipei, Taiwan,
2
Integrated
Brain Research Unit, Department of Medical Research and
Education, Taipei Veterans General Hospital, Taipei,
Taiwan,
3
Department
of Psychiatry, Taipei Veterans General Hospital, Taipei,
Taiwan,
4
Division
of Psychiatry, School of Medicine, National Yang-Ming
University, Taipei, Taiwan,
5
Department
of Computer Science, National Chiao Tung University,
Hsinchu, Taiwan
Treatment-resistant depression (TRD), with up to 20% of
patients not responding to antidepressant treatment, is
a crucial issue. Add-on repetitive transcranial magnetic
stimulation (rTMS), an emerging treatment approach for
TRD, has been reported to modulate regional brain
activity of the prefronto-thalamo-limbic system in
depressed patients. Whereas how brain structures can be
modulated by rTMS in depression remains unclear. This
study aimed to investigate, through voxel-based
morphometric analysis, the effect of rTMS on gray matter
density in TRD patients.
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