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Abstract #1990

Changes in Gray Matter Volumes Induced by Repetitive Transcranial Magnetic Stimulation in Drug-resistant Major Depression

Tai-Ying Liu 1,2 , Guan-Hua Huang 1 , Cheng-Ta Li 3,4 , Yong-Sheng Chen 5 , Tung-Ping Su 3,4 , Jen-Chuen Hsieh 1,2 , and Li-Fen Chen 1,2

1 Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, 2 Integrated Brain Research Unit, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, 3 Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, 4 Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 5 Department of Computer Science, National Chiao Tung University, Hsinchu, Taiwan

Treatment-resistant depression (TRD), with up to 20% of patients not responding to antidepressant treatment, is a crucial issue. Add-on repetitive transcranial magnetic stimulation (rTMS), an emerging treatment approach for TRD, has been reported to modulate regional brain activity of the prefronto-thalamo-limbic system in depressed patients. Whereas how brain structures can be modulated by rTMS in depression remains unclear. This study aimed to investigate, through voxel-based morphometric analysis, the effect of rTMS on gray matter density in TRD patients.

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