Cerebral Blood Flow Change in Late-life Depression: An ASL MRI Study.
Mu-Lan Jen 1 , Che-Min Lin 2 , Jasin Wong 1 , Shwu-Hua Lee 2 , Yau-Yau Wai 1,3 , and Ho-Ling Liu 1,3
Department of Medical Imaging and
Radiological Sciences, Chang Gung University, Taoyuan,
of Psychiatry, Chang Gung Memorial Hospital, Taoyuan,
of Medical Imaging and Intervention, Chang Gung Memorial
Hospital, Taoyuan, Taiwan
The purpose of this study was to evaluate the
whole-brain cerebral blood flow (CBF) change in
late-life depression (LLD) using voxelwise analysis.
Twenty-one LLD patients and seventeen elder controls
underwent background suppressed 3D pseudo-continuous
arterial spin labeling (PCASL) MRI scans. This study
showed that significant (P<0.01, corrected)
hypoperfusion in LLD in prefrontal cortex included left
rectal, subcallosal and medial frontal gyrus. Also, CBF
tend to be lower in LLD in the bilateral anterior
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