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Abstract #1989

Cerebral Blood Flow Change in Late-life Depression: An ASL MRI Study.

Mu-Lan Jen 1 , Che-Min Lin 2 , Jasin Wong 1 , Shwu-Hua Lee 2 , Yau-Yau Wai 1,3 , and Ho-Ling Liu 1,3

1 Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 2 Department of Psychiatry, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 3 Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan

The purpose of this study was to evaluate the whole-brain cerebral blood flow (CBF) change in late-life depression (LLD) using voxelwise analysis. Twenty-one LLD patients and seventeen elder controls underwent background suppressed 3D pseudo-continuous arterial spin labeling (PCASL) MRI scans. This study showed that significant (P<0.01, corrected) hypoperfusion in LLD in prefrontal cortex included left rectal, subcallosal and medial frontal gyrus. Also, CBF tend to be lower in LLD in the bilateral anterior cingulate gyrus.

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