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Abstract #1988

Differing patterns of white matter connectivity in Autism Spectrum Disorders versus Sensory Processing Disorders

Yishin Chang 1 , Julia P. Owen 1 , Shivani Desai 2 , Emily Fourie 2 , Susanna Hill 2 , Anne Arnett 2 , Julia Harris 2 , Elysa Marco 2 , and Pratik Mukherjee 1

1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States, 2 Department of Neurology, University of California, San Francisco, California, United States

Over 90% of children with Autism Spectrum Disorders (ASD) demonstrate atypical sensory behaviors. However, there are children with sensory processing differences (SPD) who do not meet other criteria for ASD diagnosis. We use probabilistic diffusion fiber tractography to compare the white matter connectivity of children with ASD and SPD to neurotypical children. Both the ASD and SPD groups demonstrate abnormal connectivity in sensory processing pathways, while the ASD group alone demonstrates abnormal connectivity in tracts thought to subserve social and emotional processing. These observations help elucidate the roles of specific neural circuits in neurodevelopmental disorders.

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