Abstract #1987
Disrupted effective connectivity in first-episode patients with major depressive disorder
zhan feng 1 , manli huang 2 , and hong yang 2
1
radiology, The First Affiliated Hospital of
College of Medicine, Zhejiang University, hangzhou,
zhejiang, China,
2
The
First Affiliated Hospital of College of Medicine,
Zhejiang University, zhejiang, China
The prefrontalClimbic network(PLN) is dysregulated in
major depressive disorders(MDD),We use the Granger
causality analysis to study variation of effective
connectivity in PLN.The decrease of effective
connectivity of prefrontal cortex proved that top-down
cognitive control function reduction existed in MDD. The
abnormality of effective connectivity from right insular
cortex to rACC showed that there was something wrong
with the SN switching function between central-executive
network and default-mode networks under the resting
state.These specific abnormal connectivities further
supplemented the dynamic active process of PLN of MDD
patients.
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