Abstract #1993
Alteration of developmental trajectory of temporal lobe grey matter in ADHD boys
Qi Liu 1 , Lizhou Chen 1 , Xinyu Hu 1 , Ying Chen 1 , Fei Li 1 , Yuanyuan Li 1 , Ning He 1 , Lanting Guo 1 , Qiyong Gong 1 , and Xiaoqi Huang 1
1
West China Hospital of Sichuan University,
Chengdu, Sichuan, China
Abnormal Gray matter volume (GMV) has been suggested to
be an important neuroimaging biomarker of Attention
Deficits/Hyperactivity Disorders (ADHD). Present study
compared GMV of drug-nave ADHD boys with well-matched
controls using voxel-based morpphometry analysis, and
explored the age effect as well as correlation with
neuropsychological measurements. Decreased GMV was
revealed in bilateral temporal lobes extending to
amygdala, which showed positive correlation with some
cognitive functions. Moreover, no significant
correlation was found between GMV with age in ADHD boys,
as seen in healthy controls, which might indicate an
abnormal developmental trajectory of GMV in ADHD.
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