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Abstract #1994

Auditory GABA Concentration Is Related to Auditory Gamma-Band Power in Normal Controls and in Autism

Mark S. Brown 1 , Sarah Steinmetz 2 , Susan L. Hepburn 3 , Deb Singel 4 , and Donald C. Rojas 5

1 Radiology, University of Colorado Denver, Aurora, CO, United States, 2 University of Colorado Denver, Aurora, CO, United States, 3 Psychiatry & Pediatrics, JFK Partners/University of Colorado School of Medicine, Aurora, CO, United States, 4 Brain Imaging Center, University of Colorado Denver, Aurora, CO, United States, 5 Psychiatry, University of Colorado Denver, Aurora, CO, United States

Auditory Gamma band MEG responses and auditory GABA levels, measured with MRS J-editing techniques, were measured in 25 healthy controls and 24 individuals with autism spectrum disorder (ASD). The results show lower GABA and transient gamma band power in the ASD subjects compared to healthy controls. Transient gamma band power correlated with GABA levels in the control group and approached significance in the ASD group. The results are consistent with our previous preliminary work suggesting that auditory gamma band responses are related to auditory GABA.

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