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Abstract #2004

Assessment of Whole Brain Temperature in Brain Injuries by 3D Echo-Planar Spectroscopic Imaging

Bhanu Prakash KN 1 , Sanjay K Verma 1 , Yevgen Marchenko 1 , Sankar Seramani 1 , Kan Enci Mary 2 , Charmaine Childs 3 , Lu Jia 2 , Andrew A Maudsley 4 , and Sendhil Velan S 1,5

1 Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 2 Combat Protection and Performance Lab, Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Singapore, 3 Centre for Health and Social Care Research, Faculty of Health and Wellbeing, Sheffield Hallam University, United Kingdom, 4 Miller School of Medicine, University of Miami, Florida, United States, 5 Clinical Imaging Research Centre, Singapore, Singapore

Measurement of in vivo temperature is of relevance in traumatic brain injuries including survival outcome of patients. Whole brain 3D MRSI approach with larger spatial coverage is highly desirable for assessing changes in cerebral metabolism and investigation of hot spots. 3D Echo-planar spectroscopic imaging (EPSI) on a pre-clinical scanner was implemented to evaluate the brain temperature changes in mild and severe traumatic brain injuries (TBI) in rodents. Brain temperature across the brain was investigated in mild and severe TBI rodents. Reduction in acquisition time along with high spatial resolution allows translation of this technology to a clinical setting, and for investigating changes in brain temperature due to TBI, stroke, cancer, epilepsy and whole brain metabolic imaging in animals and humans.

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