Abstract #2005
Improved Oxidative Metabolism and Cellular Redox State Following Sodium or Ethyl Pyruvate Supplementation after Experimental Traumatic Brain Injury
Brenda Bartnik-Olson 1 , Katsunori Shijo 2,3 , Sima Ghavim 2 , Neil Harris 2 , and Richard Sutton 2
1
Loma Linda University, Loma Linda, CA,
United States,
2
University
of California Los Angeles, Los Angeles, CA, United
States,
3
Nihon
University School of Medicine, Tokyo, Japan
Traumatic brain injury initiates a cascade of events
including increased oxidative stress that contributes to
the period of generalized metabolic depression.
Previously, sodium and ethyl pyruvate supplementation
was shown to reduce cell death, attenuate reductions in
cytochrome oxidase activity, and improve recovery
following experimental TBI. In this study we used 13C
NMR spectroscopy to determine if sodium or ethyl
pyruvate supplementation influences the activity of
metabolic pathways associated with the intracellular
redox state and oxidative metabolism. Our findings show
improvements in neuronal and astrocyte oxidative
metabolism following sodium pyruvate supplementation and
a reduction in the amount of glucose metabolized via the
pentose phosphate pathway following both sodium and
ethyl pyruvate use, suggesting an improved redox state.
These findings may explain, in part, the mechanisms
responsible for the beneficial effects of pyruvate
supplementation following experimental TBI.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
