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Abstract #2005

Improved Oxidative Metabolism and Cellular Redox State Following Sodium or Ethyl Pyruvate Supplementation after Experimental Traumatic Brain Injury

Brenda Bartnik-Olson 1 , Katsunori Shijo 2,3 , Sima Ghavim 2 , Neil Harris 2 , and Richard Sutton 2

1 Loma Linda University, Loma Linda, CA, United States, 2 University of California Los Angeles, Los Angeles, CA, United States, 3 Nihon University School of Medicine, Tokyo, Japan

Traumatic brain injury initiates a cascade of events including increased oxidative stress that contributes to the period of generalized metabolic depression. Previously, sodium and ethyl pyruvate supplementation was shown to reduce cell death, attenuate reductions in cytochrome oxidase activity, and improve recovery following experimental TBI. In this study we used 13C NMR spectroscopy to determine if sodium or ethyl pyruvate supplementation influences the activity of metabolic pathways associated with the intracellular redox state and oxidative metabolism. Our findings show improvements in neuronal and astrocyte oxidative metabolism following sodium pyruvate supplementation and a reduction in the amount of glucose metabolized via the pentose phosphate pathway following both sodium and ethyl pyruvate use, suggesting an improved redox state. These findings may explain, in part, the mechanisms responsible for the beneficial effects of pyruvate supplementation following experimental TBI.

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