Abstract #2006
Brain Network Dysfunction in Young Athletes with Persistent Post-Concussion Syndrome
Marjorie Villien 1 , Brian Edlow 2 , Elissa McIntosh 2 , Maulik P. Purohit 3 , Andre van der Kouwe 1 , Janet C. Sherman 2 , David Greer 4 , Ross Zafonte 3 , and Ona Wu 1
1
Martinos Center for Biomedical Imaging,
MGH/Harvard Medical School, Boston, MA, United States,
2
Massachusetts
General Hospital, Boston, MA, United States,
3
Spaulding
Rehabilitation Hospital, Boston, MA, United States,
4
Yale
School of Medicine, New Haven, CT, United States
Traumatic brain injury (TBI) is one of the leading
causes of morbidity in the US, with the highest
incidence among young adults. The majority of mild TBI
patients recover within a few months, but for up to 20%
symptoms persist and lead to a devastating impact on
interpersonal relationships and potentially to long-term
disability, named as persistent post-concussion syndrome
(PPCS). The pathophysiological basis of PPCS remains
unknown. This resting state fMRI study demonstrates that
multiple resting brain networks are altered in young
athletes with PPCS and also suggest that the inferior
parietal lobule is implicated in the pathogenesis of
PPCS.
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