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Abstract #2014

Mean apparent propagator MRI to determine the spatio-temporal trajectory of cortical microstructure abnormalities following controlled cortical impact in the mouse.

Elizabeth Hutchinson 1,2 , Michal Komlosh 1,2 , Alan Barnett 1,2 , Mustafa Irfanoglu 1,2 , Evren Ozarslan 1,3 , Susan Schwerin 2,4 , Sharon Juliano 2,4 , and Carlo Pierpaoli 1

1 STBB, NICHD/NIH, Bethesda, MD, United States, 2 Center for Neuroscience and Regenerative Medicine, USUHS, Bethesda, MD, United States, 3 Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 4 Anatomy, Physiology and Genetics, USUHS, Bethesda, MD, United States

We have applied the recently developed MAP-MRI framework to the investigation of brain injury. MAP-MRI provides an analytic representation of the diffusion propagator and a series of novel diffusion-MRI stains that quantify non-Gaussian water diffusion. The combination of this recent advance in diffusion modeling and the ability to quickly image fixed tissue at high spatial resolution has allowed us to identify new markers of microstructural change in the mouse cortex following controlled cortical impact and to characterize the spatio-temporal profiles of these abnormalities from 24 hours to 3 months following injury.

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