Mean apparent propagator MRI to determine the spatio-temporal trajectory of cortical microstructure abnormalities following controlled cortical impact in the mouse.
Elizabeth Hutchinson 1,2 , Michal Komlosh 1,2 , Alan Barnett 1,2 , Mustafa Irfanoglu 1,2 , Evren Ozarslan 1,3 , Susan Schwerin 2,4 , Sharon Juliano 2,4 , and Carlo Pierpaoli 1
STBB, NICHD/NIH, Bethesda, MD, United
for Neuroscience and Regenerative Medicine, USUHS,
Bethesda, MD, United States,
Brigham and Women's Hospital, Harvard Medical School,
Boston, MA, United States,
Physiology and Genetics, USUHS, Bethesda, MD, United
We have applied the recently developed MAP-MRI framework
to the investigation of brain injury. MAP-MRI provides
an analytic representation of the diffusion propagator
and a series of novel diffusion-MRI stains that
quantify non-Gaussian water diffusion. The combination
of this recent advance in diffusion modeling and the
ability to quickly image fixed tissue at high spatial
resolution has allowed us to identify new markers of
microstructural change in the mouse cortex following
controlled cortical impact and to characterize the
spatio-temporal profiles of these abnormalities from 24
hours to 3 months following injury.
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