Simulation of Diffusion Changes in Different Pathologies After Traumatic Brain Injury

In order to investigate different pathological changes influences on DTI parameters such as axial diffusivity, radial diffusivity, mean diffusivity and fractional anisotropy and to explain the contradictious clinical observations, a Monte Carlo simulation study was conducted. The preliminary results showed that, in acute stage, axonal injury and cytotoxic edema were the primary factors determining DTI parameter changes, and they could literally lead to opposite observations. In subacute stage, demyelination and vasogenic edema were the predominant factors, which affected DTI parameters in a similar way. Axial and radial diffusivity were sensitive to axonal injury and demyelination, but they were easily disrupted by edema., but they were easily disrupted by edema.

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