Abstract #2016
Multi-Modal Neuroimaging and Spectroscopy of Mild and Severe Traumatic Brain Injuries in Rodent Model
Sanjay K Verma 1 , Sankar Seramani 1 , Bhanu Prakash KN 1 , Jadegoud Yaligar 1 , Enci Mary Kan 2 , Kian Chye Ng 2 , Jia Lu 2 , and S Sendhil Velan 1,3
1
Laboratory of Molecular Imaging, Singapore
Bioimaging Consortium, Singapore, Singapore,
2
Combat
Protection and Performance Lab, DSO National
Laboratories, Singapore, Singapore,
3
Clinical
Imaging Research Centre, Singapore, Singapore
TBI is a serious and global public health issue. Fluid
percussion injury in rats is a commonly used animal
model simulating traumatic brain injuries. In this
study, we investigated the metabolic changes by MRS,
structural changes using DTI in hippocampus and changes
in microvasculature by SWI in FPI based mild and severe
TBI. Neuronal loss, membrane disruption is observed in
mild and severe injuries by MRS. The structural changes
and micro-vessel damage was observed by DTI and SWI
respectively. The combined imaging and spectroscopic
assessment provides valuable markers for investigating
structure and metabolism in mild and severe injuries.
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