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Abstract #2024

Hippocampal disconnection predicts cognitive impairment in patients with cerebrovascular disease

Dewen Meng 1 , Akram A. Hosseini 1 , Richard J. Simpson 1 , Robert A. Dineen 1 , and Dorothee P. Auer 1

1 Radiological Sciences,Division of Clinical Neurosciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Cognitive impairment is common in patients with cerebrovascular disease. The mechanisms underlying vascular cognitive impairment (VCI) have not been well established. Resting-state functional MRI has provided new insights on the functional connectivity (fc) of brain. The aim of this study was to assess fc abnormalities as potential neural substrate of cognitive impairment in patients with recently symptomatic carotid artery disease.Our findings show that VCI results from long range disconnection of the left hippocampus fc and default mode network, suggesting that fc assessed by resting-state fMRI has the potential to become a diagnostic marker that may also be useful for the assessment of treatment and rehabilitation.

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