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Abstract #2023

Cerebrovascular reactivity quantification in patients with intracranial stenosis before and after surgical revascularization

Carlos C. Faraco 1 , Lindsey M. Dethrage 1 , Meaghan A. Neill 2 , Lori C. Jordan 3 , Robert J. Singer 4 , J Mocco 5 , Paul F. Clemmons 6 , Manus J. Donahue 1,3 , and Megan K. Strother 1

1 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 2 The Medical University of South Carolina, Charleston, SC, United States, 3 Department of Neurology, Vanderbilt University, Nashville, TN, United States, 4 Section of Neurosurgery, Geisel School of Medicine at Dartmouth, Hanover, NH, United States, 5 Department of Neurosurgery, Vanderbilt University, Nashville, TN, United States, 6 Department of Radiology Nursing, Vanderbilt University, Nashville, TN, United States

Pre- and/or post-revascularization BOLD scans were acquired on non-atherosclerotic intracranial stenosis (i.e., Moyamoya disease) patients during hypercarbic hyperoxic (carbogen; 5% CO2 / 95% O2) vascular stimulation to demonstrate the effectiveness of BOLD fMRI to longitudinally monitor CVR. Patients with pre- and post-op scans continued to demonstrate significantly improved (p<.001) CVR in the operative hemisphere at the time of their second post-op scan (175 months post-op). When all patients scans were grouped by time after revascularization, significant (p<.001) improvements were seen beginning at approximately one year post-op and stabilized at approximately two years post-op.

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