Abstract #2022
Remote Ischaemic Post Conditioning is Neuroprotective in White Matter in a Piglet Model of Perinatal Asphyxia: an MRS and Immunohistochemistry Study
Alan Bainbridge 1 , Mojgan Ezzati 2 , Kevin Broad 2 , Go Kawano 2 , Aaron Oliver-Taylor 2 , Igor Fierens 2 , Jamshid Rostami 2 , Jane Hassell 2 , Ilias Tachsidis 3 , Pierre Gressens 4 , Mariya Hristova 5 , Kate Bennett 2 , Magdalena Sokolska 6 , Price David 6 , Bobbi Fleiss 4 , Derek Yellon 7 , Derek J Hausenloy 7 , Xavier Golay 8 , and Nicola J Robertson 2
1
Medical Physics, UCLH NHS Foundation trust,
London, United Kingdom,
2
Institute
for Women's Health, University College London, United
Kingdom,
3
Medical
Physics, University College London, United Kingdom,
4
Centre
for the Developing Brain, Institute of Reproductive and
Developmental Biology, Imperial College, United Kingdom,
5
Wellcome
Centre for Imaging Neuroscience, University College
London, United Kingdom,
6
Medical
Physics, UCLH NHS Foundation trust, United Kingdom,
7
The
Hatter Cardiovascular Institute, University College
London, United Kingdom,
8
Institute
of Neurology, University College London, United Kingdom
Neonatal encephalopathy is associated with high
mortality and morbidity rates worldwide. There is an
unmet need to develop novel, non-invasive approaches,
which can be used alone or in combination with
hypothermia to augment neuroprotection. The aim of this
study was to assess whether hind limb remote IPostC
after transient hypoxia-ischaemia (HI) is
neuroprotective based on 1H and 31P MRS cerebral
biomarkers and immunohistochemistry in a piglet model of
perinatal asphyxia. Remote IPostC was neuroprotective
based on reduced WM Lac/NAA at 48h and reduced TUNEL
positive cells in WM. Whole brain 31P MRS NTP/epp was
preserved with remote IPostC.
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