Propylene glycol: are levels observed in brain MRS solely related to dosing?
Robert Johnstone 1,2 , Katalin Povzai 3 , Jonathan Ashmore 4 , Nicholas Byrne 2,3 , Sarah Peel 2,3 , Ata Siddiqui 3 , Jean-Marie U-King-Im 3 , Denis Azzapardi 2 , Andrew Kapetanakis 3 , and Geoff Charles-Edwards 1,2
Guy's & St Thomas' NHS Foundation Trust,
London, London, United Kingdom,
College London, London, United Kingdom,
& St Thomas' NHS Foundation Trust, London, United
College Hospital NHS Foundation Trust, London, United
The presence of a doublet at 1.1 ppm in MRS is often
attributed to the presence of propylene glycol, a widely
used excipient. This work investigates the assumed
direct relationship between administered PG and observed
PG levels in MRS and finds a poor correlation between
the two measurements. This suggests further work is
required to elucidate the relevant of PG levels in MRS
and their any clinical relevance.
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