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Abstract #2020

Perturbed CO2 reactivity within and beyond the impact area following hyperacute mild TBI

Justin Alexander Long 1 , Qiang Shen 1 , Lora Talley Watts 1 , Shiliang Huang 1 , and Timothy Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

The initial direct mechanical damage in traumatic brain injury (TBI) is followed by secondary damage that includes impaired cerebral blood flow, autoregulation, and metabolic function. The goal of this study was to longitudinally examine the vascular reactivity to CO2 in mild TBI during hyperacute and chronic phase up to 14 days. Extensive and severe CO2 reactivity disruption beyond the impact area was observed in hyperacute TBI. Area of CO2 response abnormality appeared much larger than CBF, T2, and ADC abnormality in the hyperacute phase. T2 and CO2 reactivity mostly normalized by day 14 but mild hypoperfusion and reduced CO2 reactivity remained on day 14. These multi-parametric MRI offers complementary, clinically relevant information.

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