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Abstract #2019

Using Advanced MR Techniques to Investigate Traumatic Brain Injury

Iain David Croall 1 , Christopher Cowie 2 , Jiabao He 3 , Anna Peel 1 , Joshua Wood 1 , Benjamin Aribisala 4 , Patrick Mitchell 2 , David Mendelow 2 , Fiona Smith 1 , David Millar 5 , Thomas Kelly 2 , and Andrew Blamire 1

1 Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, 2 Newcastle upon Tyne Hospitals NHS Foundation Trust, Tyne and Wear, United Kingdom, 3 Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Aberdeen, United Kingdom, 4 Brain Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom, 5 Neurocog, Tyne and Wear, United Kingdom

Diffuse axonal injury resulting from Traumatic Brain Injury (TBI) can be investigated using advanced MR techniques. While different modalities are specialised for specific analyses, little research has combined techniques. We present a joint Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy investigation examining mildly injured TBI patients at 6 days post-injury. Regarding the DTI findings, we present a new conclusion on the previously unusual and contentious finding of increased fractional anisotropy, while a novel result of increased N-acetylaspartate and evidence of creatine alterations post-injury are reported following Spectroscopy analysis. Additionally, these physical changes are correlated with measures of cognitive functioning.

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