Routine clinical evaluation of cerebrovascular reserve capacity in patients with atherosclerotic and non-atherosclerotic intracranial stenosis using carbogen MRI
Manus Joseph Donahue 1 , Lindsey Dethrage 1 , Carlos Faraco 1 , Lori Jordan 1 , Paul Clemmons 1 , and Megan K Strother 1
Vanderbilt University, Nashville, TN, United
Carbogen (i.e., 5%CO2/95%O2)-induced measures of CVR are
potentially safer than measures elicited by other
hypercarbic gas mixtures, owing to abilities of carbogen
to increase oxygen delivery to tissue. However, carbogen
adds additional complications owing to effects of
transient hyperoxia on metabolism and increases in sPO2.
Here, we applied a carbogen MRI protocol in intracranial
stenosis patients (n=54). Findings demonstrate focal
regions of CVR discrepancy between healthy and diseased
hemispheres in patients, consistent with angiographic
measures of impairment, however only when z-statistic
markers of CVR are utilized. However, quantitative
interpretation of absolute signal changes is altered by
increases in blood [HbO2]/[Hb].
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