Abstract #2041
A statistical analysis to determine significant within-subject changes of BOLD MRI cerebrovascular reactivity to CO 2
Olivia Sobczyk 1 , Adrian Crawley 2 , Julien Poublanc 2 , Kevin Sam 2,3 , Daniel M. Mandell 2 , David Mikulis 2 , James Duffin 3,4 , and Joseph Fisher 3,4
1
Institute of Medical Science, University of
Toronto, Toronto, Ontario, Canada,
2
Department
of Medical Imaging, University Health Network, Toronto,
Ontario, Canada,
3
Department of Physiology,
University of Toronto, Toronto, Ontario, Canada,
4
Anaesthesiology,
University Health Network, Toronto, Ontario, Canada
Cerebrovascular reactivity (CVR), measured as the
cerebral blood flow (e.g. BOLD MRI) response to a
vasoactive stimulus (e.g. carbon dioxide), has been used
to gauge neurovascular function. Despite uniform test
conditions, between-test differences in CVR remain due
to variations in normal physiology and in the
measurement technology over time. We score test-to-test
changes in CVR as the z-value derived from those of a
cohort of healthy subjects tested on the same scanner.
We demonstrate this approach identifies changes between
tests that are unlikely to be attributed to physiology
and technical variation, and thus attributed to interval
change in pathology.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
