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Abstract #2044

Dilated Perivascular Spaces in the Basal Ganglia Are a Biomarker of Cerebral Small Vessel Disease in a Very Elderly Dementia Population

Thomas P Hansen 1 , John Cain 1 , Nitin Purandare 2 , Owen Thomas 3 , and Alan Jackson 1

1 Wolfson Molecular Imaging Centre, University of Manchester, Manchester, Lancashire, United Kingdom, 2 Greater Manchester Old Age Psychiatry Service, University of Manchester, Manchester, Lancashire, United Kingdom, 3 Department of Neuroradiology, Salford Royal NHS Hospitals Foundation Trust, Manchester, Lancashire, United Kingdom

We examine the discriminative power of the related perivascular spaces (PVS) in an elderly population of patients with vascular dementia, Alzheimers dementia and age-matched normal controls. We compare to previously described PVS scoring systems. The discriminative power standard white-matter scoring systems and PBS are modelled using non-linear regression. We demonstrate that PVS scores have greater significant independent discriminative power for the separation of VaD from normal and AD subjects than white matter hyper intensity scoring systems.

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