Abstract #2044
Dilated Perivascular Spaces in the Basal Ganglia Are a Biomarker of Cerebral Small Vessel Disease in a Very Elderly Dementia Population
Thomas P Hansen 1 , John Cain 1 , Nitin Purandare 2 , Owen Thomas 3 , and Alan Jackson 1
1
Wolfson Molecular Imaging Centre, University
of Manchester, Manchester, Lancashire, United Kingdom,
2
Greater
Manchester Old Age Psychiatry Service, University of
Manchester, Manchester, Lancashire, United Kingdom,
3
Department
of Neuroradiology, Salford Royal NHS Hospitals
Foundation Trust, Manchester, Lancashire, United Kingdom
We examine the discriminative power of the related
perivascular spaces (PVS) in an elderly population of
patients with vascular dementia, Alzheimers dementia
and age-matched normal controls. We compare to
previously described PVS scoring systems. The
discriminative power standard white-matter scoring
systems and PBS are modelled using non-linear
regression. We demonstrate that PVS scores have greater
significant independent discriminative power for the
separation of VaD from normal and AD subjects than white
matter hyper intensity scoring systems.
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