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Abstract #2043

IVIM Perfusion Fraction in Acute Stroke: Initial Clinical Experience

Christian Federau 1 , Suna Sumer 2 , Fabio Becce 1 , Kieran O'Brien 3 , Reto Meuli 1 , and Max Wintermark 2

1 Radiology, CHUV, Lausanne, Vaud, Switzerland, 2 Neuroradiology Division, Department of Radiology, University of Virginia, Charlottesville, Virginia, United States, 3 Center for Biomedical Imaging (CIBM), University of Geneva, Geneva, Switzerland

In the setting of acute ischemic stroke, currently used perfusion methods (DSC and CTP) may fail to properly take into account leptomeningeal collateral blood flow supply, which is essential for clinical prognosis. Perfusion measurement using IVIM might theoretically solve this issue, as it is thought to be mainly dependent on the local microvascular perfusion. We present our initial clinical experience in 17 cases of acute brain strokes (< 6 days), demonstrating that the perfusion fraction f is significantly reduced in the infarcted area.

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