Abstract #2048
An investigation of brain neurite density and dispersion in multiple sclerosis using single shell diffusion imaging
Lise Magnollay 1 , Francesco Grussu 2,3 , Claudia A.M. Wheeler-Kingshott 2 , Varun Sethi 2 , Hui Zhang 3 , Declan Chard 2,4 , David H. Miller 2,4 , and Olga Ciccarelli 1,4
1
NMR Research Unit, Department of Brain
Repair and Rehabilitation, UCL Institute of Neurology,
London, United Kingdom,
2
NMR
Research Unit, Department of Neuroinflammation, UCL
Institute of Neurology, London, United Kingdom,
3
Department
of Computer Science and Centre for Medical Image
Computing, UCL, London, United Kingdom,
4
NIHR
UCL-UCLH Biomedical Research Centre, London, United
Kingdom
Neurite Orientation Dispersion and Density Imaging (NODDI)
provides information about orientation dispersion (ODI)
and neurite density (NDI) of the underlying tissue. We
applied NODDI to single-shell brain diffusion-weighted
imaging of relapsing-remitting MS patients and healthy
controls. Patients showed (i) lower ODI in the internal
capsules and genu of the corpus callosum than controls,
(ii) lower NDI in the genu of the corpus callosum and
right occipital cortex than controls, (iii) higher FA in
the right internal capsule than controls. In patients,
lower occipital cortex NDI correlated with longer
disease duration. Therefore, NODDI parameters reflect
tissue abnormalities not detectable with FA.
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