Abstract #2049
Increased microstructural damage in the normal appearing white matter appears to distinguish SPMS from RRMS
Yunyan Zhang 1 , Bailey Komishke 2 , Luanne Metz 3 , and Lenora Brown 3
1
University of Calgary, Calgary, AB, Canada,
2
University
of British Columbia, BC, Canada,
3
University
of Calgary, AB, Canada
To understand the mechanism relating to distinct
disability, we evaluated both macroscopic and
microscopic tissue change in advanced SPMS and mild RRMS,
with a focus on the corpus callosum. We found smaller
white matter volume, not gray matter, in SPMS than in
RRMS subjects but similar T2 lesion load. Also in SPMS,
corpus callosum was atrophic, where fractional
anisotropy and radial diffusivity was significantly
compromised. No difference between mild RRMS and
controls. Our results suggest the importance of NAWM and
early intervention may protect mild RRMS patients from
developing advanced disability.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
