Functional Relevance of White Matter Degradation in Multiple Sclerosis: A Tract-Based Spatial Meta-Analysis

Relevance of tract-specific white matter degradation to clinical and cognitive functional status in multiple sclerosis (MS) has been a focus of recent research, but a consensus is yet to emerge. We present the first voxelwise meta-analysis of tract-based spatial statistics studies in MS, incorporating data across 8 studies and 358 patients. Our findings confirm widespread reductions in tract FA in MS patients in comparison to controls. Damage to white matter tracts in the corpus callosum and posterior cingulum was associated with elevated disability and cognition.

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