Meeting Banner
Abstract #2052

Comparison of efficacy of diffusion kurtosis imaging in detection of occult brain damages in neuromyelitis optica and multiple sclerosis

Wenshu Qian 1 , Koon-Ho Chan 2 , Mina Kim 1 , and Henry Ka-Fung Mak 1

1 Diagnostic Radiology, The University of Hong Kong, Hong Kong, China, 2 Medicine, The University of Hong Kong, Hong Kong, China

Early diagnosis and differentiation of neuromyelitis optica (NMO) from multiple sclerosis (MS) is vital to provide timely and proper treatment. However, conventional MRI techniques are not sensitive to assess the occult microstructural changes in brain tissues in the early or stable stage. In this study, we investigated the normal-appearing white matter and cortical gray matter in controls and patients with NMO and MS using diffusion kurtosis imaging (DKI). Our results demonstrate that DKI-derived indices are sensitive to detect the microstructural abnormalities and can distinguish pathological alterations in NMO from MS, suggesting DKI may be a useful diagnostic tool of NMO.

This abstract and the presentation materials are available to members only; a login is required.

Join Here