Abstract #2054
MS diagnosis is predicted at initial clinical presentation by venocentric lesions detected with 3T SWI
Matthew P Quinn 1,2 , Marcelo Kremechutzky 3 , and Ravi S Menon 1,2
1
Centre for Functional and Metabolic Mapping,
Robarts Research Institute, London, Ontario, Canada,
2
Medical
Biophysics, Western University, London, Ontario, Canada,
3
Clinical
Neurological Sciences, Western University, London,
Ontario, Canada
Visualizing white matter hyperintensities (WMHs) with
MRI is a critical step in diagnosing multiple sclerosis
(MS), but WMHs are also present in other diseases. The
presence of central veins within WMHs may be specific to
MS. In this study, healthy controls (HCs) and patients
with clinically isolated syndromes (CIS) suggestive of
MS were imaged with FLAIR (to identify WMHs) and SWI (to
identify veins). After clinical follow up, it was
determined that all CIS patients who were diagnosed with
MS within the 11 month study window had more than 40%
lesions with central veins at clinical presentation.
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