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Abstract #2054

MS diagnosis is predicted at initial clinical presentation by venocentric lesions detected with 3T SWI

Matthew P Quinn 1,2 , Marcelo Kremechutzky 3 , and Ravi S Menon 1,2

1 Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario, Canada, 2 Medical Biophysics, Western University, London, Ontario, Canada, 3 Clinical Neurological Sciences, Western University, London, Ontario, Canada

Visualizing white matter hyperintensities (WMHs) with MRI is a critical step in diagnosing multiple sclerosis (MS), but WMHs are also present in other diseases. The presence of central veins within WMHs may be specific to MS. In this study, healthy controls (HCs) and patients with clinically isolated syndromes (CIS) suggestive of MS were imaged with FLAIR (to identify WMHs) and SWI (to identify veins). After clinical follow up, it was determined that all CIS patients who were diagnosed with MS within the 11 month study window had more than 40% lesions with central veins at clinical presentation.

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