Abstract #2058
What explains gray matter atrophy in long-standing multiple sclerosis?
Martijn D. Steenwijk 1 , Marita Daams 1,2 , Petra Pouwels 3 , Lisanne J. Balk 4 , Prejaas K. Tewarie 4 , Joep Killestein 4 , Bernard M.J. Uitdehaag 4 , Jeroen J.G. Geurts 2 , Frederik Barkhof 1 , and Hugo Vrenken 1,3
1
Department of Radiology and Nuclear
Medicine, VU University medical center, Amsterdam,
Noord-Holland, Netherlands,
2
Department
of Anatomy and Neurosciences, VU University medical
center, Amsterdam, Noord-Holland, Netherlands,
3
Department
of Physics and Medical Technology, VU University medical
center, Amsterdam, Noord-Holland, Netherlands,
4
Department
of Neurology, VU University medical center, Amsterdam,
Noord-Holland, Netherlands
Gray matter (GM) atrophy is common in multiple sclerosis
(MS), but the relation with white matter (WM) pathology
is largely unknown. We aimed to identify the WM measures
that explain whole brain GM, cortical and subcortical
atrophy in a large cohort (n=208) of long-standing MS
patients using stepwise linear regression. WM atrophy
and lesion volume were the most important measures
explaining whole brain and subcortical atrophy, while
cortical atrophy was associated with NAWM integrity
loss. The weaker relationship between GM atrophy and WM
pathology in progressive patients might indicate a more
independent neurodegenerative disease process in these
patients.
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