Abstract #2059
White matter abnormalities are associated with cognitive dysfunction in secondary progressive multiple sclerosis
K.A. Meijer 1 , M. Cercignani 2 , N. Muhlert 1 , V. Sethi 1 , D. Chard 1,3 , M. Ron 1 , A.J. Thompson 1,3 , D.H. Miller 1,3 , J.J.G. Geurts 4 , and O. Ciccarelli 1,3
1
NMR Unit, Queen Square MS Centre, UCL
Institute of Neurology, London, United Kingdom,
2
Clinical
Imaging Sciences Centre, Brighton and Sussex Medical
School, Brighton, United Kingdom,
3
NIHR
University College London Hospitals, Biomedical Research
Centre, London, United Kingdom,
4
Department
of Anatomy and Neuroscience, VU University Medical
Centre, Amsterdam, Netherlands
We investigated whether loss of white matter integrity
is associated with cognitive dysfunction in secondary
progressive (SPMS) patients using tract-based spatial
statistics (TBSS). Cognitively impaired patients showed
a more extensive loss of WM integrity than cognitively
preserved patients; most pronounced differences were
observed in the fornix, corpus callosum, forceps major,
right inferior longitudinal fasciculus and right
uncinate fasciculus. In patients, the DTI metrics of
many of these tracts showed significant correlations
with processing speed and visual memory processing,
suggesting that disruption in these tracts may result in
a disconnection syndrome which is responsible for
cognitive impairment in MS.
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